Acomplia represents one of the latest and indeed a most novel method for controlling body weight. It operates by being a cannabinoid receptor antagonist. This means that it prevents the normal action of endogenous cannabinoid in the brain from stimulating the so-called CB1 receptors. It would appear that these receptors stimulate appetite and therefore when they are subdued so is the need to eat.

With specific regard to weight loss, the human trials have shown an average weight loss of 10% of bodyweight, most importantly that weight has remained off even up to 2-years later. Also importantly, it would appear that the majority of weight is actually lost from the difficult to lose area around the waist. The average figures from the trials show a loss of fat of 20 lbs (9 Kg) and 3 inches (8 cm) diameter taken off the waist.

Acomplia has also been shown to improve HDL (good cholesterol), cardiovascular factors such as cholesterol ratios and triglyceride levels, showing benefit for diabetes and heart conditions by subduing receptors which stimulate appetite.